Differences Between Lipase And Amylase
Oct 06, 2022
Lipase (LPS) is mainly produced in the acinar cells of the pancreas. It can hydrolyze a variety of water-insoluble long-chain fatty acid glycerides and has a certain specificity for long-chain fatty acid glycerides. Serum LPS mainly comes from the pancreas, and a small amount comes from the gastrointestinal mucosa. In normal blood, there is only a small amount of lipase, which is easily cleared by the kidneys. When the pancreas is hypersecreted, the pancreatic duct is blocked, or the pancreas is damaged or necrotic, the lipase flows back or is directly released into the blood, which increases the activity of lipase in the blood. Lipase can be filtered by the glomerulus and fully absorbed by the renal tubules, so lipase activity cannot be detected in urine.
Amylase (AMY) is mainly secreted by salivary glands and pancreas. It belongs to the class of hydrolases and catalyzes the hydrolysis of starch and glycogen. There are two main isoenzymes of amylase in serum, namely isoenzyme P (derived from pancreas) and isoenzyme S (derived from salivary glands and other tissues). The pancreatic juice secreted by the human pancreas contains amylase, which enters the duodenum through the pancreatic duct for hydrolysis. Due to the small molecular weight of amylase, it can enter the blood through microcirculation and be filtered in the glomerulus, so amylase can also be detected in urine, and the increase of AMY in urine is slower than that in serum.
● The human pancreas contains the most AMY, the salivary glands also secrete a large amount of AMY into the mouth, and it is also found in the ovary, lung, testis, striated muscle and adipose tissue.
● LPS in serum mainly comes from pancreas, and a small amount comes from gastrointestinal mucosa. Compared with AMY, LPS has higher tissue specificity.
